In another study, Chen et al. elucidated that miR-506 and miR-124 levels were significantly reduced in human colorectal cancer (CRC) tissues and that miR-506 and miR-124 inhibited progression and enhanced sensitivity to chemotherapy by downregulating DNMT3B and DNMT1 in CRC [21]. The gene discussed is DNMT3B; the disease is colorectal carcinoma.