Interestingly, the increased CD21low B-cells and decreased memory B-cells displayed by PKCδ-deficient patients resemble findings of the subgroup CVID Ia from the Freiburg classification [71], which presents with impaired BCR-mediated calcium response [72] and shows higher frequency of splenomegaly and autoimmune cytopenias [71, 72]. Here, PRKCD is linked to Splenomegaly.