ITGAL and systemic lupus erythematosus: Reduction of PKCδ phosphorylation at Thr505 due to oxidative stress and nitration of PKCδ prompts decreased ERK signaling in T cells of SLE patients, which leads to reduced DNMT1 activity and hypomethylation of regulatory sequences of sensitive genes such as LFA1 (encoding CD11a) and TNFSF7 (encoding CD70), therefore causing T-cell activation and contributing to T-cell autoimmunity.