This study has revealed de novo variants in the ankyrin repeat containing proteins AGAP6 and ANKRD31 in RTT-like patients, and the presence of de novo variant of the SH3 and multiple ankyrin repeat domain3 protein (SHANK3) (Hara et al. 2015) and ankyrin-3 (ANK3) (Grillo et al. 2013) has been reported in two RTT-like patients. This evidence concerns the gene EHMT2 and Rett syndrome.