Our exome sequencing effort indicated that probands originally diagnosed as RTT-like patients were, in fact, carriers of well-known pathogenic de novo mutations linked to Dravet Syndrome (SCN1A), myoclonic-atonic epilepsy (SCLC6A1), or early infantile epileptic encephalopathies 24 (HCN1) and 27 (GRIN2B). This evidence concerns the gene GRIN2B and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.