Serum concentrations of extracellular nicotinamide phosphoribosyltransferase (eNAMPT; also referred to as visfatin/pre-B cell colony-enhancing factor [PBEF]) are commonly elevated in type 2 diabetes patients [2], whilst raised eNAMPT levels strongly correlate with declining beta cell function [3]. This evidence concerns the gene NAMPT and type 2 diabetes mellitus.