TGFB1 and neoplasm: Conversely, one of the most extreme examples of UB site gain by a TSG occurs in the previously unstudied ATP50-TGFB1 fusion (Figure 5B), which results in the amalgamation of a heavily ubiquitinated segment with a short portion of the TGFB1 tumor suppressor domain, hinting at a fusion-mediated loss of TSG function.