Further, p75NTR has been reported to influence glucose uptake in adipocytes via Glut4 by directly binding the trafficking regulators Rab5 and Rab3133, to controls energy expenditure in obese mice on a high-fat diet by inhibiting cAMP signaling in adipocytes via direct association of p75NTR with protein kinase A34, and to promote fibrinolysis in nerve injury and lung fibrosis by binding and enhancing the cAMP degradative activity of phosphodiesterase PDE4A4/535. The gene discussed is NGFR; the disease is pulmonary fibrosis.