VPS35 and Parkinson disease: Evidence of Mn interaction with PD-related gene products [parkin (PARK2), DJ-1 (PARK7), PINK1 (PTEN-induced putative kinase 1, PARK6), ATP13A2 (PARK9), and SLC30A10 as well as LRRK2 (leucine-rich repeat kinase 2, PARK8) and VPS35 (vacuolar protein sorting-associated protein 35, PARK17] has been reviewed (Roth, 2014) and it is likely that genetic predisposition combined with Mn exposure accelerates PD onset.