rs2116709 at 3p13 (P=5.7 × 10−16, OR=0.91, logistic regression) resides within an intron of FOXP1, a transcription factor that, in addition to regulating organ development, acts as a tumour suppressor in some cancers (for example, prostate33) and as an oncoprotein in others (for example, oesophagus34). Here, FOXP1 is linked to cancer.