This link between PRR5L, TTP, and TNFα is interesting in light of recent studies demonstrating the association of a SNP (rs4755450) in PRR5L with juvenile idiopathic arthritis, and a microarray study showing that down-regulation of PRR5L was associated with osteoarthritis in adults (Chiaroni-Clarke et al. 2014; Wang et al. 2015). This evidence concerns the gene PRR5L and osteoarthritis.