For example, the gene encoding the forkhead transcription factor, FOXC1, which is an important biomarker of basal-like breast cancer (Jensen et al. 2015), is lowly expressed at time zero, exhibits a brief but significant increase in expression, and then stabilizes at a new equilibrium state ∼5 h after estrogen stimulation (Fig. 2B). This evidence concerns the gene FOXC1 and breast carcinoma.