Identifying the gene(s) which shows synthetic (dosage) lethal interactions24 with MYCN or MYC amplification may help the development of promising strategies for the treatment of MYCN- or MYC-driven cancers because inhibiting genes that show synthetic lethality with MYC or MYCN amplification would selectively kill cancer cells25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36. This evidence concerns the gene MYCN and cancer.