This is in agreement with the expression peak of IRF-4 at day 3, a key transcription factor of M2 polarization phenotype, whereas expression of IRF-8, a transcription factor of M1 polarization phenotype, increases within 72 h after ischemia (Guo et al. 2014; Xiang et al. 2014). This evidence concerns the gene IRF8 and ischemia.