Hh pathway activation, underlying NF‐kB and FOXC1‐induced expansion of stem cell‐like tumor cells in TNBC, also occurs in a ligand‐independent fashion via direct potentiation of GLI1 expression and GLI2 activity, by NF‐kB and FOXC1, respectively 45, 90. This evidence concerns the gene FOXC1 and neoplasm.