It is a complex transdifferentiation process, orchestrated by several transcription factors (Zeb1/2, Snail1, Snail2 (Slug), Twist 1/2, Goosecoid, FOXM1, FOXC1, and FOXC2 among others) endowing breast tumor cells with enhanced self‐renewal, tumor initiating capacity, invasiveness and resistance to apoptosis 26, 28, 96, 97, 98. The gene discussed is SNAI2; the disease is neoplasm.