SMO and squamous cell lung carcinoma: Autocrine SMO‐dependent signaling: Loss of HHIP or increased HH ligand expression via SOX2‐mediated regulation of hedgehog acetyltransferase HHAT expressiona)Ligand (SMO)‐independent signaling: Direct GLI2 activation by FGFR1 through MAPK signaling (squamous cell lung cancer)Likely non‐canonical SMO‐dependent signaling (cytoskeletal rearrangement in lung cancer cells) Paracrine stromal signaling (lung fibroblasts)