The effects of RES on inducing apoptosis in pancreatic cancer cells by multiple molecular targets in STAT3 or NFкB inflammatory pathways have been reported12, 30, however, the effects of TRES on inducing apoptosis, and the effects of RES and TRES on cooperation and interaction between STAT3 and NFкB, which may contribute to inducing apoptosis in pancreatic cancer cells, have not been investigated. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.