In order to investigate whether RES and TRES induce apoptosis of pancreatic cancer cells by STAT3 or NFκB signaling pathway, we made cytoplasmic and nuclear fractions of PANC-1 cells treated with TRES or RES and analyzed them by Western blotting to measure the levels of STAT3 and NFκB signaling molecules. The gene discussed is STAT3; the disease is familial pancreatic carcinoma.