In order to investigate whether RES and TRES induce apoptosis of pancreatic cancer cells by STAT3 or NFκB signaling pathway, we made cytoplasmic and nuclear fractions of PANC-1 cells treated with TRES or RES and analyzed them by Western blotting to measure the levels of STAT3 and NFκB signaling molecules. Here, NFKB1 is linked to familial pancreatic carcinoma.