Interestingly, 27/38 (71 %) of bladder cancer samples which, showed +3 over-expression patterns of Her2/neu protein have amplification (> 2) of their corresponding Her2/neu gene while only 29 % (11/38) of over-expressed Her2/neu proteins showed non-amplified (< 2) Her2/neu gene, respectively. The gene discussed is ERBB2; the disease is urinary bladder cancer.