Gene enrichment analysis of primary tumor microarray data demonstrated PLK1 associated gene signatures including the G2M checkpoint (NES = 1.55, p < 0.05) and mitotic spindle assembly (NES = 1.7, p < 0.05) were also higher in DIPG tumors compared to normal pons (Fig. 1c). The gene discussed is PLK1; the disease is diffuse intrinsic pontine glioma.