CSF3 and retinal ischemia: Granulocyte colony-stimulating factor (G-CSF) is a neuroprotectant that has been used in many ON/retina animal models, including ON axotomy or crush injury, light-induced retinal damage, retinal ischemia and reperfusion, and oxygen-induced retinopathy (Tsai et al., 2008; Oishi et al., 2008; Frank et al., 2009; Shima et al., 2012).