For further analysis of the immunological mechanisms involved in the growth inhibition of lymphosarcoma RLS-40 after virus injection, and given the evidence of the virus-mediated induction of various pro-inflammatory mediators and cytokines, we assessed the kinetics of GM-CSF, IFN-γ, TNF-α and IL-6 in the serum of RLS-40-bearing mice treated with the virus or PBS. Here, TNF is linked to lymphoma.