p53 expression was correlated with grading (rho = 0.499, p = 0.002), cyclin E (rho = 0.335, p = 0.046), PAI-1 in the extracellular matrix (rho = 0.444, p = 0.007), Her-2 (rho = 0.368, p = 0.027) and p16 (rho = 0.514, p = 0.001) expression, first suggesting key interactions and potential synergy with other key drivers of tumor malignancy. The gene discussed is ERBB2; the disease is neoplasm.