Major discriminant parameters were shown to be, HER-2, p53, p16, Cyclin E, PgR, together with stromal cathepsin D, PAI-1, uPA and MMP-11 were found to markedly contribute to the classification model; these efficiently clustered with local relapse, lymph node diffusion, tumor staging and grading. This evidence concerns the gene CDKN2A and neoplasm.