Indeed, we found that Atm−/− mice that presented with visible abnormalities in the thymus at sacrifice (apparently enlarged thymus or visible tumor) had significantly lower blood glutamine (0.6 ± 0.09 mM) than Atm−/− mice with normal thymus (1.0 ± 0.09 mM – p < 0.01) (Fig. 6). The gene discussed is ATM; the disease is neoplasm.