FCGR2B rs1050501 (c.695T > C) codes a non-synonymous substitution, Ile232Thr (I232T) on chromosome 1q23.3 (161644048), our meta-analysis showed that C allele significantly increased the risk of SLE under recessive association model and allelic test model in overall population (Table 3, Fig. S2a; Supplementary Fig. S2b). This evidence concerns the gene FCGR2B and systemic lupus erythematosus.