To assess the association of FCGR2B rs1050501 polymorphism with SLE, 13 studies were included in this meta-analysis with 2970 cases and 4197 controls, however, we identified publication bias while the study by Kobavashi T et al. 59 was included (Begg’s Test: Z = 2.14, P = 0.033), therefore, this study was removed in the final analysis with 2899 cases and 4153 controls. This evidence concerns the gene FCGR2B and systemic lupus erythematosus.