We subjected wild-type (WT, LysMCre−/VEGF+/+) and mutant mice carrying Lewis lung carcinomas (LLCs) or B16F10 (B16) melanomas to three cycles of cisplatin treatment (cis-diamminedichloridoplatinum(II) (cisplatin, CDDP), 8 mg per kg body weight, see scheme Fig. 1a). The gene discussed is VEGFA; the disease is melanoma.