Consistently, chemotherapy with another frequently used cytotoxic agent, etoposide, resulted in improved chemotherapeutic outcome in LLC-bearing Mut mice, increased chemerin expression in tumour ECs, enhanced NK cell recruitment and decreased senescent tumour cells (Supplementary Fig. 6A–D, respectively) but failed to increase systemic chemerin levels (Supplementary Fig. 6E), further supporting a link between systemic chemerin levels and protection against cachexia. This evidence concerns the gene RARRES2 and neoplasm.