Our results showed that in tested tumor cell lines of various origins, which predominantly express distinct members of the TP53 family, certain intermediates of autophagic pathway are transcriptionally regulated, thereby contributing to the induction (ATG1/ULK1 in RKO1 cells), vesicle nucleation (ATG6/BECN1, UVRAG1 in U87-MG cells and RKO cells), and vesicle expansion (ATG5, ATG7, and ATG10 in U87-MG cells, and SCC-11 cells). Here, ATG5 is linked to neoplasm.