TP53 and hepatocellular carcinoma: Finally, cardamonin (2′,4′-dihydroxy-6′-methoxychalcone) from Alpinia katsumadai Hayata (Zingiberaceae) inhibited cell proliferation, induced G2/M phase cell cycle arrest, and enhanced autophagy in human hepatocellular carcinoma HCT116 cells, and these processes were regulated by TP53 [44].