TP53 and neoplasm: We found that in contrast to the scrambled RNA (Scr RNA), siRNA against TP63, TP73, and TP53 markedly decreased the protein levels of predominant isoforms ΔNp63α, TP73α, and TP53 in the tested tumor cells (SCC-11, U87-MG, and RKO) even upon subsequent exposure of the tumor cells to the selected marine compounds (CA2, PMA, and ILQ), as shown in Figure 7.