While phosphorylation of TP53 family members is often critical for the activation of TP53 proteins as transcription factors, the specific phosphorylation events (S385 for ΔNp63α Y99 for TP73α, and S15 and S46 for TP53) have also been found to serve as biomarkers underlying the role of TP53 family members in reducing tumor cell survival and inducing cell death via multiple mechanisms [29,30,45]. This evidence concerns the gene TP53 and neoplasm.