Finally, we examined whether the silencing of TP53 family members (TP53, TP63, and TP73) would affect the transcriptional regulation of selected autophagic genes (ATG1/ULK1, ATG5, ATG6/BECN1, ATG7, ATG10, and UVRAG) in the tested tumor cells (SCC-11, U87-MG, and RKO) upon treatment with marine anticancer compounds (CA2, PMA, and ILQ). The gene discussed is BECN1; the disease is neoplasm.