Serum IL-1β levels of AOSD patients (3.11 ± 2.34 pg/mL) were higher than those of HCs (1.57 ± 0.58, p = 0.004), and the TNF-α levels of AOSD patients (6.63 ± 5.13 pg/mL) were also higher than those of HCs (2.84 ± 1.58 pg/dL, p = 0.002). This evidence concerns the gene IL1B and adult-onset Still disease.