SERPING1 and angioedema: Our work allowed us also to identify 18 patients displaying an asymptomatic decrease in C1INH function, which was previously described in 6 patients with lymphoid disease.[26,27] These cases were of asymptomatic C1INH deficiencies, and our description of clinical remission of angioedema occurrences without normalization of C1INH function raises some questions regarding the mechanisms that induce angioedema.