Immunohistochemically, many liver-specific proteins, including AFP, glypican-3, HepPar1, albumin, transferin, and alpha-1-antitrypsin, have been detected in the cytoplasm of HAC cells.[24–26] Liu et al reported a case of HAC from the jejunum arising in ulcerative colitis, in which the hepatoid components were immunohistochemically positive for CK8, CK18, and CK19, AFP, HepPar1, and polyclonal carcinoembryonic antigen (pCEA; canalicular pattern), and negative for CK7 and CK20.[21] In this case, a strong positivity with hepatocyte suggested the presence of tumors with hepatoid differentiation. The gene discussed is AFP; the disease is ulcerative colitis.