IL22 and psoriasis: IL-22 is a key pathogenic cytokine in psoriasis, as it can trigger regenerative and proliferative programmes in keratinocytes, inhibit their differentiation, and activate the inflammatory cascade, inducing proinflammatory molecules.39 It is released by T helper type 17 (Th17) and Th22 subsets, mainly targets keratinocytes in the skin, and triggers STAT3-dependent pathways.39 We evaluated whether LUT-7G could antagonize IL-22 signalling cascade activation in keratinocytes and restore the differentiated phenotype.