The counterintuitive downregulation of Mcl-1 in CRC specimens might be due to its unique role in DNA damage repair.10 A similar pattern showing a loss of Mcl-1 and an acquirement of Bcl-xL has been described by Krajewska et al.15 In case of Bcl-2, we did not observe changes in the expression level, indicating a non-redundant and organ-specific function of these anti-apoptotic proteins. The gene discussed is MCL1; the disease is colorectal carcinoma.