SPRC could enhance the interaction between VEGFR2 and STAT3 as well as promote STAT3 nuclear translocation and its transcriptional activation of downstream promoters, particularly the Vegf promoter in human umbilical vein endothelial cells.23 Intriguingly, our present investigation elucidated that SPRC rapidly elevated STAT3 phosphorylation and nuclear translocation through a gp130-mediated mechanism in normal H9c2 cardiomyocytes (Figure 1), which further shed light on the beneficial role of SPRC in STAT3-related cardiovascular diseases. The gene discussed is SPRR3; the disease is cardiovascular disorder.