STAT3 and myocardial infarction: The signal transducer and activator of transcription 3 (STAT3) is an essential molecule downstream of gp130, which is activated under various stressful conditions, such as pressure-overload and myocardial infarction.1 For gp130-triggered STAT3 activation, gp130 is firstly phosphorylated by JAK, and the side chains of gp130 serve as docking sites for latent transcription factors of STAT3.