CRHR1 and obesity due to melanocortin 4 receptor deficiency: However, among the genes included in the female WC gene set, three may be interesting: CRHR1, NOS3, and FARS2. CRHR1 is a genome-wide significant locus for bone-mineral-density [46] and a suggestive locus for infant head circumference [47], and it is also involved in stress, reproduction, immune response, and obesity [48, 49].