BECN1 and breast carcinoma: Kumar et al reported that Rottlerin induced autophagosome formation through conversion of LC3-I to LC3-II, up-regulation of Atg12 and Beclin-1, and inhibition of anti-apoptotic proteins including Bcl-2, Bcl-xL, XIAP, and cIAP-1 in breast cancer stem cells [47].