The top affected upstream regulator was CRX (P < 0.001), which has a known role in the development and maintenance of photoreceptors.23,24 Another significantly affected upstream regulator was NR2E3 (P < 0.001), which is important for photoreceptor development and has been implicated in inherited retinal dystrophies.25 In addition, 386 clusters of noncoding RNAs (microRNAs, small nucleolar RNAs, long noncoding RNAs) demonstrated significant changes in expression in eyes injected with CD34+ cells compared with PBS-injected eyes. This evidence concerns the gene NR2E3 and inherited retinal dystrophy.