TGFB1 and uveitis: CD14++CD16+ intermediate monocytes from noninfectious uveitis patients, unlike classical and nonclassical monocytes, have strong immunoregulatory effects, such as a reduced capacity to activate T-cell effector functions, as we showed earlier.15 Furthermore, the immunosuppressive cytokine TGF-β1 was upregulated in supernatants from monocyte cultures with EV released by nonstimulated RPE but not in control cultures that did not contain EV.