For example, apical localization of wg RNA is essential for signal activation in epithelial cells (Simmonds et al., 2001; Wilkie and Davis, 2001), whilst the RNA binding protein RBM47 regulates Wnt signaling in zebrafish head development (Guan et al., 2013) as well as in cancer (Vanharanta et al., 2014; Venugopal et al., 2015). Here, RBM47 is linked to cancer.