HER4 overexpre- ssion was associated with the depth of tumor invasion (OR = 0.50, 95%CI 0.30–0.83, P = 0.0007) (Fig 2D) and lymph node metastasis (OR = 0.57, 95%CI 0.38–0.86, P = 0.0007) (Fig 2E). This evidence concerns the gene ERBB4 and metastatic malignant neoplasm in the lymph nodes.