ERBB3 and metastatic malignant neoplasm in the lymph nodes: The combined data showed that the HER3-positive expression was tightly related to the depth of tumor invasion (OR = 0.44, 95%CI 0.29–0.67, P = 0.0002) (Fig 2A), lymph node metastasis (OR = 0.40, 95%CI 0.20–0.77, P = 0.007) (Fig 2B), recurrence (OR = 0.10, 95%CI 0.03–0.34, P<0.0001), and vascular invasion(OR = 0.51, 95%CI 0.27–0.96, P = 0.026).