TBXA2R and polycythemia: TT can also promote VTE via increased blood pressure,14 polycythemia,15,16 decrements in high-density lipoprotein cholesterol,14,16 blood hyperviscosity, and platelet aggregation.16, -18 Intramuscular TT increases platelet thromboxane A2 receptor density and platelet aggregation,19 increasing adhesion to the coronary artery endothelium and thrombus formation, with subsequent plaque rupture and acute coronary syndrome.20 Dihydrotestosterone can promote acute coronary events through enhanced monocyte activation.21,22