TP53 and ovarian cancer: The TP53 mutation frequency varies across cancer types, with high-grade serous ovarian carcinomas exhibiting the highest frequency at 96% (Bell et al., 2011; Cerami et al., 2012; Gao et al., 2013), suggesting that TP53 mutations are critical drivers for the development of this subtype of ovarian cancer (Ahmed et al., 2010).