Investigation of Lrrc10 homozygous knockout (Lrrc10−∕−) mice (Manuylov et al., 2008) has led to recent discoveries linking LRRC10 to the molecular etiology of DCM (Brody et al., 2012; Qu et al., 2015). This evidence concerns the gene LRRC10 and familial dilated cardiomyopathy.