LRRC10 and familial dilated cardiomyopathy: Although the reduced contractile response of isolated Lrrc10−∕− myocytes to β-adrenergic stimulation (Brody et al., 2016) could be a consequence of DCM in Lrrc10−∕− mice, it could also be explained by a primary function for LRRC10 in coupling adrenergic stimulation to myofilament contraction by facilitating excitation-contraction coupling.