PTGDS has been also identified to be down-regulated in the senescence-accelerated SAMP8 mouse model (Alvarez-Lopez et al., 2013), as well as in the Tg4-42 mouse model of AD, where long-term physical activity led to an amelioration of hippocampal neuron loss and a rescue of behavioral deficits (Huttenrauch et al., 2016). Here, PTGDS is linked to Alzheimer disease.