The kinase signalling subgroup, includes characteristic mutations in REarranged during Transfection (RET) in Multiple Endocrine Neoplasia type 2 (MEN2), Neurofibromatosis type 1 (NF1), transmembrane protein 127 (TMEM127), MYC associated factor X (MAX), EGLN1 (PHD2), KIF1 and IDH1 [6]. This evidence concerns the gene TMEM127 and multiple endocrine neoplasia type 2.