MFN2 and Cognitive impairment: In view of protective effect of increased expression of Mfn2 on mild cognitive impairment (MCI)-impaired mitochondrial fusion/fission balance and mitochondrial alteration7, we propose that generation of Mfn2 agonists may hold potential for preventing or treating of neurodegenerative diseases including Alzheimer’s disease8 by augmenting mitochondrial function and neurogenesis.