IGF2 and major depressive disorder: Animal and human studies report that IGF2 is associated with developmental abnormalities in the structure and/or function of the cerebellum (Pidsley et al., 2012) and the hippocampus (Chen et al., 2011; Ouchi et al., 2013), both of which are associated with ADHD (Castellanos et al., 2002; Plessen et al., 2006), as well as other psychiatric disorders such as depression and schizophrenia (Yu, Shen, Zeng, Ma, & Hu, 2013).