ACTA1 and pulmonary fibrosis: Similar to genetic ablation of α6 in lung mesenchymal cells, we observed that administration of T-5224 during the post-inflammatory fibrotic phase abrogated bleomycin injury-induced experimental lung fibrosis in mice (Fig. 5d, hydroxyproline content; Fig. 5e, immunoblot for fibronectin and α-SMA; Fig. 5f, Masson's trichrome staining; Fig. 5g, micro-CT analysis of aerated lung volume).