Expression level of Wee1 during cocaine (p < 0.01), HIV-infection (p < 0.001), cocaine exposure with HIV infection (p < 0.01), SWI/SNF expression levels due to cocaine (p < 0.02), HIV-infection (p < 0.03) and cocaine exposure with HIV infection (p < 0.02) altered significantly. The gene discussed is SMARCA1; the disease is HIV infectious disease.