In the present study, we have shown for the first time that cocaine with HIV infection or HIV-1 gp120 protein impact additively the of ATP utilization, ECR/OCAR ratio (Fig. 1), ROS production and activation of AMPKs, and CDC25B, CDC25C, MAP/Tau and Wee1 expression (Figs 2 and 3) associated with inhibition of mitochondrial oxidative phosphorylation. This evidence concerns the gene ITIH4 and HIV infectious disease.