Among the novel results consistently associated in both the discovery and replication datasets at the 3-digit level was a variant in KCNH2 (rs1137617) a gene known to cause long QT syndrome with ICD-9 codes 244 “Acquired hypothyroidism” (Pdiscovery = 5.31x 10-3 and Preplication = 1.15x10-3). The gene discussed is KCNH2; the disease is hypothyroidism.