SGCE and limb-girdle muscular dystrophy: DYT11 M‐D is caused by loss‐of‐function mutations in SGCE that lead to the absence or reduction of the ɛ‐sarcoglycan protein at the plasma membrane.7, 11, 12, 13 ɛ‐Sarcoglycan is a member of the sarcoglycan family of transmembrane glycoproteins.14, 15 Mutations in the genes encoding α‐, β‐, γ‐, and δ‐sarcoglycan cause different limb girdle muscular dystrophies (LGMD2C‐F).