Currently, there is very limited published information on the concordance of IHC, in situ hybridisation (ISH) and non-in situ tests for the detection of ROS1 gene rearrangements in lung adenocarcinoma [36, 37, 42, 58]; less than 30 cases with gene rearrangements have been subjected to comparative study of the three methods. This evidence concerns the gene ROS1 and lung adenocarcinoma.