ANO6 and Scott syndrome: By applying these sensitive proteomics techniques to platelets of a patient with the congenital Scott syndrome with mutations in the ANO6 gene, and a complex altered phenotype (deficiency in Ca2+-dependent swelling, PS exposure and protein cleavage), we could obtain detailed insight into the changes in post-translational protein modifications after stimulation of the platelets with strong Ca2+-mobilizing agonists; and moreover, into the suspected role of the Ca2+-dependent ion channel anoctamin-6 into these changes.