The main findings were that (i) combining biomarkers improved the diagnostic accuracy for AD versus CN compared to using individual biomarkers; (ii) T‐tau and Ng were highly correlated and associated with Aβ pathology across clinical stages of AD, while NFL correlated with cognitive decline independent of Aβ pathology; and (iii) T‐tau and Ng were associated with acceleration of cognitive decline, atrophy, and hypometabolism primarily in the presence of Aβ pathology, while NFL was associated with decline independent of Aβ pathology. Here, NEFL is linked to Mental deterioration.