Furthermore, we determined the potential influence of CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1 on CRP serum levels at RA diagnosis and also at the time of the carotid US study. The gene discussed is NLRP3; the disease is rheumatoid arthritis.