Taking together all this information, the aim of the present study was to evaluate the potential influence of CRP, HNF1A, LEPR, GCKR, NLRP3, IL1F10, PPP1R3B, ASCL1, HNF4A and SALL1, polymorphisms related to elevated CRP serum levels in non-rheumatic Caucasians, on the development of CV events and subclinical atherosclerosis in RA patients. The gene discussed is LEPR; the disease is rheumatoid arthritis.