It is the case for common genetic variants that play a role in the immune system (NLRP3 [NACHT, LRR and PYD domains-containing protein 3] rs12239046 or IL1F10 [interleukin-1 family, member 10] rs6734238) or in the susceptibility to develop metabolic syndrome (HNF1A [hepatic nuclear factor 1-α] rs1183910, LEPR [leptin receptor] rs4420065, GCKR [glucokinase regulator] rs1260326 and HNF4A [hepatocyte nuclear factor 4-α] rs1800961)12. The gene discussed is IL1F10; the disease is metabolic syndrome.