However, we could not find an association between the elevated CRP serum level-related variants in non-rheumatic Caucasians and the presence of subclinical atherosclerosis or CV events in RA patients.The lack of evidence for the association between these polymorphisms and atherosclerosis in RA patients does not exclude the implication of CRP in the pathogenesis of this disease. The gene discussed is CRP; the disease is rheumatoid arthritis.